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Image Search Results
Journal: Molecular & Cellular Proteomics : MCP
Article Title: Accurate MS-Based Diagnostic Amyloid Typing Using Endogenously Normalized Protein Intensities in Formalin-Fixed Paraffin-Embedded Tissue
doi: 10.1016/j.mcpro.2025.101040
Figure Lengend Snippet: Standard amyloidosis cases consistent with IHC or clear-cut based on clinical background. Heatmaps illustrating amyloid typing of clear-cut amyloidosis samples, where proteomics results were consistent with IHC staining (ATTR ( A ), Alλ ( B ), Alκ ( C ), AA ( D )) or determination of amyloidosis type was consistent with the histological context (ACal ( E )). Additionally, a mixed/double amyloidosis case was confirmed by LC-MS/MS to include both kappa light chains and TTR ( F ). Whole-dissected samples are indicated with an asterisk (∗).
Article Snippet: After incubation with the antibodies (Transthyretin (Dako, Code No. A0002), Amyloid A (Dako, Code No. M0759), Kappa Light Chains (Dako, Code No. A0191),
Techniques: Immunohistochemistry, Liquid Chromatography with Mass Spectroscopy